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Human Trials Now Begin for Preventive Vaccine for Parkinson’s Disease

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A new study, led by the Institute for Molecular Medicine (IMM) and the National Institute of Aging in collaboration with the University of California, Irvine, and the University of California, San Diego, describes four vaccines designed to generate high levels of antibodies specific to various regions of pathological α-Synuclein, the protein associated with Parkinson Disease (PD), Dementia with Lewy bodies (DLB), and other synucleinopathies, including Alzheimer’s disease (AD).

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Of these four vaccines, the best results were obtained with PV-1950, which simultaneously targets three B cell epitopes of this pathological molecule, showing the most significant reduction of α-Synuclein and neurodegeneration in the brains of vaccinated hα-Syn D line mice.            

Dr. Agadjanyan said, “The development of a safe and immunogenic vaccine targeting all forms of pathological α-Synuclein is IMM’s goal. Importantly, our most effective vaccine, PV-1950, generated strong antibody production, reducing pathological α-Synuclein and improving motor deficits in a mouse model of disease is ready to be tested in preventive clinical trials”. He continued, “The PV-1950 has two versions – one based on DNA and one on recombinant protein. Complementary prime-boost immunization with heterologous DNA and protein vaccines is an alternative and promising approach to elicit greater antibody responses.”

PD is the second most prevalent neurodegenerative disorder of aging that affects both motor and cognitive function. The institute looks to the vaccine-based preventative treatment of neurodegenerative diseases such as PD, DLB, and AD. An immunogenic vaccine could be the most effective way to block/inhibit the aggregation of toxic α-Synuclein protein from the accumulation and spreading in the brains and halt or delay the disease, said IMM.

“α-Synuclein is a neuronal protein that is linked genetically and neuropathologically to various α-synucleopathies, including Parkinson’s disease (PD). Once pathology begins, it becomes virtually impossible to stop it, so using MultiTEP platform-based vaccine from IMM Nuravax want to halt or delay the disease in people at risk of α-synucleopathies,” said Roman Kniazev.

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Editor in chief is Linda Hohnholz.

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  • My husband was diagnosed of Parkinsons disease 2 years ago, when he was 59. He had a stooped posture, tremors, right arm does not move and also a pulsating feeling in his body. He was placed on Senemet for 8 months and then Siferol was introduced and replaced the Senemet, during this time span he was also diagnosed with dementia. He started having hallucinations, lost touch with. Suspecting it was the medication I took him off the Siferol (with the doctor’s knowledge)  him on PD natural herbal formula we ordered from TREE OF LIFE HEALTH CLINIC, his symptoms totally declined over a 3 weeks use of the TREE OF LIFE HEALTH Parkinson’s disease natural herbal formula. He is now  almost 61 and doing very well, the disease is totally reversed!  (w w w. treeoflifeherbalclinic .com)